Enzyme found to disrupt Ebola replication

first_imgApr 15, 2005 (CIDRAP News) – The Ebola virus has yielded an important behavioral clue that could lead to a treatment for the incurable infection that kills 50% to 90% of its victims, researchers have announced.Enzyme-inhibiting chemicals have stalled the virus’ reproduction in laboratory-grown cells, reports senior author James M. Cunningham, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, in an article published online yesterday in Science. The research was partly supported by the National Institute of Allergy and Infectiuos Diseases (NIAID), part of the National Institutes of Health (NIH).The researchers found two cellular enzymes the Ebola virus depends upon to reproduce. When they are blocked, the virus’ infectivity drops a great deal, according to a news release from NIAID.The Ebola virus uses the cellular enzymes to cut up viral surface proteins. Once the protein is split, the virus can multiply.Scientists applied broad-spectrum enzyme inhibitors to mammal cells before exposing them to Ebola. When an enzyme called cathepsin B was suppressed, the infectivity of the Ebola virus “dropped to near zero,” the news release said.The other enzyme, cathepsin L, played a helping role in Ebola multiplication, researchers found. Drugs that inhibit cathepsins are already being developed to fight cancer.The findings may be significant because Ebola, like its fellow filovirus Marburg, is part of a family of viruses that strike relatively rarely but can cause severe, often fatal hemorrhagic fevers. An ongoing Marburg outbreak in the Uige province of Angola had as of yesterday sickened 235 people, killing 215.”Finding medical countermeasures for viral hemorrhagic fevers is a global public health priority because not only do these diseases occur naturally, but they also have the potential to be unleashed by bioterrorists,” says NIH Director Elias A. Zerhouni, MD.The research illuminates the mechanism the Ebola virus uses to insinuate itself into cells, said NIAID Director Anthony S. Fauci, MD. “These findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.Chandran K, Sullivan NJ, Felbor U, et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005 (published online Apr 14) http://www.sciencemag.org/cgi/content/abstract/1110656v1See also: NIH news release at http://www.nih.gov/news/pr/apr2005/niaid-14.htm.last_img read more

Phil Collins helps ‘childhood hero’ Jimmy Greaves with donation during illness

first_imgROCK LEGEND Phil Collins has made a “substantial donation” to help former England star Jimmy Greaves in his battle against illness.The ex-Chelsea, West Ham and Tottenham striker was admitted to hospital last week and the Genesis drummer – who says Greaves is a “childhood hero” – is doing his bit to help out.3 Rock legend Phil Collins has made a ‘substantial donation’ to help his ‘childhood hero’ Jimmy Greaves who is in hospital3 Greaves was admitted to hospital in Essex last week with an un-specified conditionGreaves has struggled with health problems since he suffered a stroke nearly five years ago and Spurs confirmed he was admitted to hospital near his Essex home last Tuesday.No specific condition has been mentioned but the 80-year-old is not believed to have contracted coronavirus or suffered another stroke.And Greaves’ agent Terry Baker gave an update on the legendary striker’s condition saying “no news is good news” and revealed how lifelong Tottenham fan Collins is helping out.CHELSEA NEWS LIVE: Follow for the latest Blues newsHe said told the Star: “Phil Collins phones me regularly to see how Jimmy is and made a substantial donation.We have had thousands of people enquiring after Jimmy and sending love.”We thank you for that from the bottom of our hearts. It’s still a case of no news is good news at the moment.”Jimmy isn’t a well man but he is in hospital receiving the best possible care thanks to the amazing doctors and nurses of the NHS at this difficult time for everyone.”Greaves now uses a wheelchair and is cared for around the clock by family and professional carers who visit him several times each day.MOST READ IN FOOTBALLTHROUGH ITRobbie Keane reveals Claudine’s father was ’50-50′ in coronavirus battleTOP SELLERGavin Whelan has gone from League of Ireland to David Beckham’s InstagramPicturedAN EYEFULMeet Playboy model and football agent Anamaria Prodan bidding to buy her own clubI SAW ROORodallega saw Rooney ‘drinking like madman’ & Gerrard ‘on bar dancing shirtless’ExclusiveRIYAD RAIDMan City’s Riyad Mahrez has three luxury watches stolen in £500,000 raidNEXT STEPJonny Hayes set to move to English Championship having been let go by CelticREF RELEASEDChampions League ref Vincic released by cops after arrest in prostitution raidKEANE DEALEx Man United youth ace David Jones says Roy Keane negotiated a contract for himHe retired almost 49 years ago, but he still holds the record of most goals in the English top flight with 357.Greaves is also still at the top of the pile for Tottenham after scoring a record 266 goals in 379 appearances.The legendary forward also bagged 44 goals in 57 games for England and was part of the 1966 World Cup winning squad.3 The Genesis drummer is a lifelong Spurs fanHarry Redknapp speaks emotionally about the great Jimmy Greaves who is recovering in hospitallast_img read more