Enzyme found to disrupt Ebola replication

first_imgApr 15, 2005 (CIDRAP News) – The Ebola virus has yielded an important behavioral clue that could lead to a treatment for the incurable infection that kills 50% to 90% of its victims, researchers have announced.Enzyme-inhibiting chemicals have stalled the virus’ reproduction in laboratory-grown cells, reports senior author James M. Cunningham, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, in an article published online yesterday in Science. The research was partly supported by the National Institute of Allergy and Infectiuos Diseases (NIAID), part of the National Institutes of Health (NIH).The researchers found two cellular enzymes the Ebola virus depends upon to reproduce. When they are blocked, the virus’ infectivity drops a great deal, according to a news release from NIAID.The Ebola virus uses the cellular enzymes to cut up viral surface proteins. Once the protein is split, the virus can multiply.Scientists applied broad-spectrum enzyme inhibitors to mammal cells before exposing them to Ebola. When an enzyme called cathepsin B was suppressed, the infectivity of the Ebola virus “dropped to near zero,” the news release said.The other enzyme, cathepsin L, played a helping role in Ebola multiplication, researchers found. Drugs that inhibit cathepsins are already being developed to fight cancer.The findings may be significant because Ebola, like its fellow filovirus Marburg, is part of a family of viruses that strike relatively rarely but can cause severe, often fatal hemorrhagic fevers. An ongoing Marburg outbreak in the Uige province of Angola had as of yesterday sickened 235 people, killing 215.”Finding medical countermeasures for viral hemorrhagic fevers is a global public health priority because not only do these diseases occur naturally, but they also have the potential to be unleashed by bioterrorists,” says NIH Director Elias A. Zerhouni, MD.The research illuminates the mechanism the Ebola virus uses to insinuate itself into cells, said NIAID Director Anthony S. Fauci, MD. “These findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.Chandran K, Sullivan NJ, Felbor U, et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005 (published online Apr 14) http://www.sciencemag.org/cgi/content/abstract/1110656v1See also: NIH news release at http://www.nih.gov/news/pr/apr2005/niaid-14.htm.last_img read more

Over 9,300 personnel deployed to secure Jakarta as omnibus law protests enter 2nd week

first_imgWidespread protests erupted across the country after the House of Representatives passed the bill on Oct. 5.Some protests, however, have been marred by violent clashes between protesters and security forces.Meanwhile, civil society organizations have slammed the police for using “excessive force” in managing the demonstrations as pictures of police assaulting protesters and journalists circulated on social media.The Commission for Missing Persons and Victims of Violence (Kontras) said it had received at least 1,500 reports on alleged police violence from Oct. 6 to 8 during the planned national strike against the new law, organized primarily by labor unions. (trn) The police also deployed 200 Brimob officers to West Java.Awi added that a joint force of 9,332 policemen, soldiers and Public Order Agency (Satpol PP) officers had been deployed in the capital on Tuesday to enforce security.Read also: ‘We are not yet defeated’: Students condemn govt’s dismissal of jobs law protestsWhile Tuesday’s protest in Jakarta involved several religious groups, the country’s second largest Islamic organization, Muhammadiyah, reasserted that it would not take part in any demonstrations. Instead, it would “focus on handling the COVID-19 outbreak and its impact on education, the economy and public health”, Muhammadiyah secretary Abdul Mu’ti said on Monday, as quoted by tribunnews.com. The National Police on Monday deployed around 7,500 Mobile Brigade (Brimob) officers to ensure public safety and security in Jakarta amid continuing protests against the newly passed Job Creation Law, or omnibus law.Several groups, including the hard-line Islam Defenders Front (FPI) and the 212 Alumni Brotherhood (PA 212), went ahead with their planned demonstrations on Tuesday in Jakarta to demand that the government revoke the omnibus law.“The first deployment of [Brimob officers] arrived in Jakarta on Oct. 5, while the second arrived on Oct. 12. At least 7,500 officers are deployed here,” National Police spokesperson Brig. Gen. Awi Setiyono said on Monday as quoted by kompas.com.center_img Topics :last_img read more

Obafemi dreams of emulating Bale,Oxlade-Chamberlain

first_img Loading… ‘He likes sailing,’ the young forward begins. ‘So we went sailing as a team.’ Staff versus players, it was an attempt by Southampton’s manager to build morale and unity among his squad. The staff won, and on this day the prankster gets his way, too. Obafemi’s concentration drifts as outside Nathan Redmond distracts his team-mate with comedic gestures. ‘I’m laughing at him, sorry,’ Obafemi says. In the 19-year-old’s short senior career, Redmond has become something of a mentor and older brother. He advises the Republic of Ireland international on ‘simple stuff,’ such as where he should be on the pitch and what he should eat off it. On Boxing Day they combined to down Chelsea, netting either side of half-time to secure a valuable three points at Stamford Bridge. ‘It was a sweet feeling, for sure,’ Obafemi tells Sportsmail. ‘To get such an important goal for the team was incredible. It was a huge win for us. I was so happy for Nathan, too, as he has been a big influence for me.’ It was Obafemi’s second Premier League goal — and his first for more than a year. Now the forward, who stopped playing for a year after being released by Watford, stands among them. ‘I want to carry on going, make my family proud and do as much as I can.’ Obafemi, who is not 20 until July, has always been in a hurry. Promoted ContentYou’ve Only Seen Such Colorful Hairdos In A Handful Of AnimeWhat Happens When You Eat Eggs Every Single Day?10 Risky Jobs Some Women DoFantastic-Looking (and Probably Delicious) Bread ArtEverything You Need To Know About Asteroid ArmageddonTop 10 Most Romantic Nations In The World10 Phones That Can Work For Weeks Without Recharging8 Superfoods For Growing Hair Back And Stimulating Its Growth10 Places On Our Planet Where The Most People Live2020 Tattoo Trends: Here’s What You’ll See This YearThe Very Last Bitcoin Will Be Mined Around 2140. Read More14 Hilarious Comics Made By Women You Need To Follow Right Now Southampton’s rising star, Michael Obafemi is dreaming  of emulating Gareth Bale, Alex Oxlade-Chamberlain and Adam Lallana: ‘If they can do it, why not me?’ ‘I remember when I was at nursery all the other kids used to ride bicycles around, but I just sprinted round in circles,’ he says. ‘I think that’s when I knew I was fast.’ By secondary school, other students were at least trying to join in. ‘We used to do little 100m races and I remember on my sports day, we had like an announcer,’ he recalls before impersonating her high-pitch voice. ‘When I was sprinting, she was like: “Is it a bird? Is it a plane? No it’s Michael Obafemi!”‘ In his mid-teens he was crowned the fastest boy in his borough with a time of 10.8 seconds. For context, when Dina Asher-Smith broke her own British Championship record back in August, she ran 10.96sec. ‘I never trained. I used to just turn up,’ admits Obafemi. That was until football became his sole focus. Hasenhuttl has given Obafemi and other young players crucial game time even as the club battle to stay in the Premier League. Now, after an injury-ravaged year, he is firmly back in the manager’s plans. Read Also:Southampton confirm Obafemi’s blackout against Crystal Palace ‘He’s been a big influence on my career. He’s believed in me, he thinks I’m a “cool guy” as he said to the media,’ Obafemi says. So would he return the compliment? ‘Yeah,’ Obafemi laughs. ‘I’d say so, we have a good relationship!’ Last month, however, the Saints boss warned his young charge that the road remains long. ‘He still has a lack of professionalism in his whole life,’ Hasenhuttl said. FacebookTwitterWhatsAppEmail分享 last_img read more