Enzyme found to disrupt Ebola replication

first_imgApr 15, 2005 (CIDRAP News) – The Ebola virus has yielded an important behavioral clue that could lead to a treatment for the incurable infection that kills 50% to 90% of its victims, researchers have announced.Enzyme-inhibiting chemicals have stalled the virus’ reproduction in laboratory-grown cells, reports senior author James M. Cunningham, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, in an article published online yesterday in Science. The research was partly supported by the National Institute of Allergy and Infectiuos Diseases (NIAID), part of the National Institutes of Health (NIH).The researchers found two cellular enzymes the Ebola virus depends upon to reproduce. When they are blocked, the virus’ infectivity drops a great deal, according to a news release from NIAID.The Ebola virus uses the cellular enzymes to cut up viral surface proteins. Once the protein is split, the virus can multiply.Scientists applied broad-spectrum enzyme inhibitors to mammal cells before exposing them to Ebola. When an enzyme called cathepsin B was suppressed, the infectivity of the Ebola virus “dropped to near zero,” the news release said.The other enzyme, cathepsin L, played a helping role in Ebola multiplication, researchers found. Drugs that inhibit cathepsins are already being developed to fight cancer.The findings may be significant because Ebola, like its fellow filovirus Marburg, is part of a family of viruses that strike relatively rarely but can cause severe, often fatal hemorrhagic fevers. An ongoing Marburg outbreak in the Uige province of Angola had as of yesterday sickened 235 people, killing 215.”Finding medical countermeasures for viral hemorrhagic fevers is a global public health priority because not only do these diseases occur naturally, but they also have the potential to be unleashed by bioterrorists,” says NIH Director Elias A. Zerhouni, MD.The research illuminates the mechanism the Ebola virus uses to insinuate itself into cells, said NIAID Director Anthony S. Fauci, MD. “These findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.Chandran K, Sullivan NJ, Felbor U, et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005 (published online Apr 14) http://www.sciencemag.org/cgi/content/abstract/1110656v1See also: NIH news release at http://www.nih.gov/news/pr/apr2005/niaid-14.htm.last_img read more

Chelsea cancel training after major coronavirus scare

first_img La Liga has been suspended for two weeks, while UEFA will hold an emergency meeting on Tuesday to address the fate of this season’s major European competitions. Chelsea’s players were ordered not to turn up for training on Thursday amid a coronavirus scare. According to The Athletic, someone ‘close to the squad’ complained they were suffering with COVID-19-like symptoms and a decision was made on Thursday morning to cancel training. Chelsea were forced to cancel Thursday’s training session amid a coronavirus. The report claims that the unidentified person has not yet been diagnosed with coronavirus. Chelsea’s players are due to train on Friday ahead of Saturday’s Premier League match against Aston Villa. Chelsea’s Champions League fixture against Bayern Munich next week was already scheduled to be played behind closed doors, while manager of Premier League rivals Leicester, Brendan Rodgers, revealed on Thursday that three of his players were currently in self-isolation having been suffering with symptoms. Manchester City’s Champions League clash, meanwhile, with Real Madrid is in severe jeopardy with the Spanish club in lockdown after one of their basketball players was struck down with the virus.Advertisement Loading… Read Also: UEFA to discuss coronavirus in Tuesday meeting A statement read: ‘In the light of the ongoing developments in the spread of COVID-19 across Europe and the changing analysis of the World Health Organisation, UEFA has today invited representatives of its 55 member associations, together with the boards of the European Club Association and the European Leagues and a representative of FIFPro, to attend meetings by videoconference on Tuesday 17 March to discuss European football’s response to the outbreak. ‘Discussions will include all domestic and European competitions, including UEFA EURO 2020. ‘Further communication will be made following those meetings.’ FacebookTwitterWhatsAppEmail分享 Promoted Content6 Extreme Facts About Hurricanes6 Ridiculous Health Myths That Are Actually True9 Actors Who Stay Famous For That One Movie They Did 10 Years Ago6 Incredibly Strange Facts About HurricanesWhich Country Is The Most Romantic In The World?Did You Know There’s A Black Hole In The Milky Way?20 Celebs With Surprising Hidden Talents And Skills8 Superfoods For Growing Hair Back And Stimulating Its GrowthInsane 3D Spraying Skills Turn In Incredible Street Art9 Facts You Should Know Before Getting A TattooWhat Women Find The Most Attractive In Men From The 60-sFantastic-Looking (and Probably Delicious) Bread Artlast_img read more

Man City legend rejects ‘one man team’ claims following Champions League heroics

first_imgManchester City legend Dennis Tueart insists the Blues’ character to progress to the Champions League knockout stages without Sergio Aguero disproved recent claims they are a one man team.City have endured a somewhat indifferent run of form throughout the early stages of this season, with Argentine star Aguero carrying the side at times with 19 goals in all competitions.Doubts were raised over their chances to progress in Europe’s premier club competition, therefore, when the striker was ruled out of Wednesday’s must-win clash at Roma after suffering a knee injury in the Premier League.But – despite missing a host of other key first-teamers – Manuel Pellegrini’s men certainly delivered as Samir Nasri and Pablo Zabaleta found the net in a 2-0 victory.And Tueart believes Pellegrini has a team to be reckoned with after booking their place in the last 16.“We have a really big squad and they proved they can deliver as a team with the win at Roma,” he told The Sports Bar.“We know City don’t have to rely on the likes of Aguero, [Vincent] Kompany, [David] Silva and [Yaya] Toure to get results now.“Individual belief will be growing game by game and other teams will be thinking: ‘If anybody goes to Rome and wins 2-0 they got to have something about them’.“And with Aguero, Silva, Kompany and Toure all coming back, I think we’ll certainly have a team to be reckoned with, that’s for sure.”last_img read more