Enzyme found to disrupt Ebola replication

first_imgApr 15, 2005 (CIDRAP News) – The Ebola virus has yielded an important behavioral clue that could lead to a treatment for the incurable infection that kills 50% to 90% of its victims, researchers have announced.Enzyme-inhibiting chemicals have stalled the virus’ reproduction in laboratory-grown cells, reports senior author James M. Cunningham, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, in an article published online yesterday in Science. The research was partly supported by the National Institute of Allergy and Infectiuos Diseases (NIAID), part of the National Institutes of Health (NIH).The researchers found two cellular enzymes the Ebola virus depends upon to reproduce. When they are blocked, the virus’ infectivity drops a great deal, according to a news release from NIAID.The Ebola virus uses the cellular enzymes to cut up viral surface proteins. Once the protein is split, the virus can multiply.Scientists applied broad-spectrum enzyme inhibitors to mammal cells before exposing them to Ebola. When an enzyme called cathepsin B was suppressed, the infectivity of the Ebola virus “dropped to near zero,” the news release said.The other enzyme, cathepsin L, played a helping role in Ebola multiplication, researchers found. Drugs that inhibit cathepsins are already being developed to fight cancer.The findings may be significant because Ebola, like its fellow filovirus Marburg, is part of a family of viruses that strike relatively rarely but can cause severe, often fatal hemorrhagic fevers. An ongoing Marburg outbreak in the Uige province of Angola had as of yesterday sickened 235 people, killing 215.”Finding medical countermeasures for viral hemorrhagic fevers is a global public health priority because not only do these diseases occur naturally, but they also have the potential to be unleashed by bioterrorists,” says NIH Director Elias A. Zerhouni, MD.The research illuminates the mechanism the Ebola virus uses to insinuate itself into cells, said NIAID Director Anthony S. Fauci, MD. “These findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.Chandran K, Sullivan NJ, Felbor U, et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005 (published online Apr 14) http://www.sciencemag.org/cgi/content/abstract/1110656v1See also: NIH news release at http://www.nih.gov/news/pr/apr2005/niaid-14.htm.last_img read more

Local kids will ‘Shop with a Cop’ this holiday season

first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisALPENA, Mich. – The Department of Health and Human Services handpicked a group of lucky boys and girls to shop with a cop this holiday season. The Alpena Police Department is giving back to help 12 students fulfill wishes on their Christmas list.The department partnered with local law enforcement agencies, Walmart and local credit union partners to provide kids with gift cards for shopping and a free breakfast.Alpena High School Liaison Officer Tim Marquardt says the program has been going strong since 2003 — the year it all began.“In those 15 years, those events have really struck a cord with the community and our officers who don’t mind getting on their uniforms and volunteering their time,” says the officer. “They don’t get paid to do this, and for that couple hours have a chance to bond with those kids, and build a rapport with those kids, and help these kids have a little bit brighter Christmas.” AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisContinue ReadingPrevious Tuesday’s Werth Road house fire updateNext Last week of brush pickups for city residents onlylast_img read more

Sellas Tetteh’s Sierra Leone in danger of crashing out of WCup qualifiers

first_imgSierra Leone’s 2018 World Cup hopes are in danger after they lost the first leg of their preliminary round qualifier 1-0 against Chad in Ndjamena on Saturday.The Sellas Tetteh-led Leone Stars, featuring nine foreign-based players, conceded the goal in the 47th minute of the game after Leger Djimrangar struck.Both teams clash in the decisive second leg of the tie on Tuesday in the southern Nigerian city of Port-Harcourt.The winner on aggregate will tackle seven-time African champions Egypt in the second round of the knockout phase of the qualifiers next month.In other qualifiers played today, Madagascar hammered hosts Central African Republic 0:3 to take a giant step towards booking their place in the next round. In the game played in Bangui, Fetraniaina Rabeson gave the Malagasy the lead in the 27th minute, and Nijva Rakotoharimalala doubled the advantage six minutes from the break. Johann Paul then capped the win in the 65th minute.Elsewhere, Polokwane City of South Africa midfielder Galabgwe Moyana and another PSL star Joel Mogorosi of Bloemfontein Celtic, scored in the 22nd and 64th minutes respectively to help Botswana beat hosts Eritrea 0-2 in Asmara. –last_img read more

Emotion, passion of fans at Hearts-Aduana game relived by Andie Tenoso

first_imgSunday afternoon at the Accra Stadium, Aduana Stars and Hearts of Oak played a match that upset fans on both sides.As I approached the stadium, morale was high and the excitement in the stadium woke my sleepy mind and widened my tired eyes.I had never been to a football match in Ghana before and it was not what I expected.Some fans sat quietly and would occasionally yell something; while others had drums they would dance and sing no matter the events happening on the field.I attended the game with 13 other classmates as we are studying abroad here in Ghana. Majority of us have never been to Ghana or a football game here. We were welcomed with chants and banter about the teams.Coming from a college in America, the University of Oregon, a school that does not have a football (also known as soccer) team, it was a completely different sporting event we are used to. Fans of all ages engaged in the game, it seemed to be an escape from reality for a moment or two. Football being a distraction from work or school, releasing one from any worry you might have.As the match came to a close, I had picked up an uneasy feeling. The voices I heard spoke different languages but they all seemed slightly angry.The match ended in a draw. While fans were crowding out of the hot stadium I overheard complaints, fans were saying they had wasted their money on an uneventful game.There was a general consensus among the fans I questioned on whether they would have watched their team lose rather than there being no victor or loser crowned for the crowd to cheer or weep over.At least they would have seen a goal, a bit of action on the field validating the money they had spent on tickets and snacks. –Follow Joy Sports on Twitter: @JoySportsGH. Our hashtag is #JoySportslast_img read more