Enzyme found to disrupt Ebola replication

first_imgApr 15, 2005 (CIDRAP News) – The Ebola virus has yielded an important behavioral clue that could lead to a treatment for the incurable infection that kills 50% to 90% of its victims, researchers have announced.Enzyme-inhibiting chemicals have stalled the virus’ reproduction in laboratory-grown cells, reports senior author James M. Cunningham, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, in an article published online yesterday in Science. The research was partly supported by the National Institute of Allergy and Infectiuos Diseases (NIAID), part of the National Institutes of Health (NIH).The researchers found two cellular enzymes the Ebola virus depends upon to reproduce. When they are blocked, the virus’ infectivity drops a great deal, according to a news release from NIAID.The Ebola virus uses the cellular enzymes to cut up viral surface proteins. Once the protein is split, the virus can multiply.Scientists applied broad-spectrum enzyme inhibitors to mammal cells before exposing them to Ebola. When an enzyme called cathepsin B was suppressed, the infectivity of the Ebola virus “dropped to near zero,” the news release said.The other enzyme, cathepsin L, played a helping role in Ebola multiplication, researchers found. Drugs that inhibit cathepsins are already being developed to fight cancer.The findings may be significant because Ebola, like its fellow filovirus Marburg, is part of a family of viruses that strike relatively rarely but can cause severe, often fatal hemorrhagic fevers. An ongoing Marburg outbreak in the Uige province of Angola had as of yesterday sickened 235 people, killing 215.”Finding medical countermeasures for viral hemorrhagic fevers is a global public health priority because not only do these diseases occur naturally, but they also have the potential to be unleashed by bioterrorists,” says NIH Director Elias A. Zerhouni, MD.The research illuminates the mechanism the Ebola virus uses to insinuate itself into cells, said NIAID Director Anthony S. Fauci, MD. “These findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.Chandran K, Sullivan NJ, Felbor U, et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005 (published online Apr 14) http://www.sciencemag.org/cgi/content/abstract/1110656v1See also: NIH news release at http://www.nih.gov/news/pr/apr2005/niaid-14.htm.last_img read more

Coronavirus: Why have so many died in New York?

first_imgGovernor Andrew Cuomo has said repeatedly that density and number of foreign visitors made New York City, which has almost 93,000 confirmed cases, an ideal breeding ground for infectious disease.America’s financial capital has 8.6 million inhabitants. There are 10,000 people per square kilometer, making it the densest city in the US.Millions of commuters brush up against each other on its packed subway system every day, while keeping distance on its sometimes narrow sidewalks can be difficult.NYC gets more than 60 million tourists a year and is the entry point to America for many travelers, meaning anyone carrying the virus is likely to start infecting others there first.  American geneticists estimate that it started spreading there from Europe in February, before New York’s first confirmed case on March 1. The Big Apple is also characterized by massive socioeconomic inequality. Overcrowded, deprived areas — particularly in the Bronx and Queens, where many people already suffer health problems and lack medical care — have experienced the highest rate of infections.”New York City had all the preconditions that would support the idea that it was going to be hit very hard,” said Irwin Redlener, public health professor and expert in disaster preparedness at Columbia University.Did officials underestimate risk? On March 2, as the state’s second case was confirmed in New Rochelle, just north of New York City, Cuomo said the health care system was the best “on the planet.””We don’t even think it’s going to be as bad as it was in other countries,” he added.After much hesitation, New York City Mayor Bill de Blasio announced the closure of public schools, bars and restaurants from March 16.The governor ordered all non-essential businesses to close and residents to stay at home a week later on March 22.Experts hesitate to say that they waited too long.”The mayor and the governor were being pushed and pulled by two opposing forces. “One was saying we have to close schools and restaurants as quickly as possible, the other saying there were lots of economic and social consequences of shutting down everything early,” said Redlener.”Everyone was getting mixed messages, including from the federal government, from (President Donald) Trump,” he added.Have other states reacted better? California, America’s most populous state, is often cited as a good example for the speed of its response to the outbreak. Its confirmed cases as of Friday were just 20,200, with 550 deaths.On March 16, six counties in the San Francisco Bay area issued a stay-at-home order followed by the whole state three days later.”One thing that I think is significant is that six neighboring counties got together and issued the same (confinement) order for all six counties, and they did it early,” said Meghan McGinty, associate at school of public health of Johns Hopkins University.”There was consistency, as opposed to NYC taking one measure, and Westchester (county) taking another, and Long Island taking another,” she told AFP.Six days passed between New York’s school closure order and its order confining residents to their homes.”In epidemic terms, six days is light years and can really make a difference in the control and spread of the epidemic, so I think it is possible to say that perhaps, in retrospect, New York waited too long,” said McGinty.Is anyone to blame? When the crisis passes, the blame game may begin.Democrats Cuomo and de Blasio deplored for weeks the Trump administration’s delay in getting tests to states, which to this day are still not arriving in sufficient numbers.The New York officials also targeted the federal government for dragging its heels in implementing emergency powers to manufacture lifesaving ventilators.With the toll far exceeding the numbers killed on 9/11, Phil Murphy, the governor of neighboring New Jersey, which has also been badly affected, has called for a commission similar to the one set up to investigate the September 11, 2001 attacks.”The warning signs were there… what happened? If you don’t know the answer, how are you going to make sure it’s not going to happen again?” Cuomo asked Friday.Given the number of dead and millions of unemployed, “we have a moral obligation to study this pandemic,” concluded McGinty.Topics : New York has more coronavirus cases than any country and accounts for around half of all deaths in the United States. Why was is so badly hit and could its leaders have done anything differently?Was New York more vulnerable? As of Friday, New York state has almost 160,000 confirmed COVID-19 infections, more than Europe’s worst-hit countries of Spain and Italy, and over 7,800 deaths.last_img read more

Saipem Reduces Q4 Deficit; Books €12M Profit in 2019

first_imgItalian offshore services player Saipem has reported fourth-quarter 2019 loss of €32 million on revenues of €2.35 billion.This result compares to net loss of €115 million on revenues of €2.47 billion in the prior-year comparable period.Adjusted result was net profit of €74 million, against €8 million profit in Q4 2018.Saipem reported Q4 2019 EBITDA of €280 million (€206 million in Q4 2018) and €1.15 billion for the full year 2019.Contract awards in 2019 are valued at approximately €20 billion when including new contracts awarded by non-consolidated companies.Reported backlog stands at close to €25 billion, against €14.5 billion at December 31, 2018.For the twelve months of 2019, Saipem generated profit of €12 million on revenues of €9.1 billion, versus net loss of €472 million on revenue of €8.5 billion in 2018.In 2020, revenues are expected to be approximately €10 billion, with adjusted EBITDA above of €1.1 billion and capex of approximately €600 million.Subsea World News Stafflast_img read more

Wildcats Defeated By Spartans

first_imgFC lost a closely fought, physical battle against Connersville 2-1.They controlled most of the game but simply could not find that finishing touch again. The lone goal was a Cledith Martin header produced by rebound off of a Tommy Ratz free kick which caromed off the top goalpost.Courtesy of Wildcats Coach Daniel Gartenman.last_img

Best hails ‘ruthless’ Schmidt

first_img “It’s ruthless, but that’s where you want to be. This is a ruthless level we’re playing at: we’re playing the best teams in the world, the best players in the world. “You go back to 12 months ago, you make one small error and you lose a game. “On Saturday we didn’t and that is ingrained in us now that you stick to the system. “You trust the guy to your right and the guy to your left, and ultimately we have systems and protocols in place that can win you games in tight situations.” Former Leinster boss Schmidt gritted his teeth through suspected appendicitis to stay on hand and direct operations against Australia, before heading off for medical tests at full-time. Doctors at the Aviva Stadium sent Schmidt to Dublin’s St Vincent’s Hospital, where his condition was confirmed and he underwent surgery to have his appendix removed. The ex-Clermont coach was recuperating on Sunday following the successful operation, the Irish Rugby Football Union (IRFU) confirmed. Ireland cemented their status as the number-three side in the world rankings on Saturday, backing up their 29-15 South Africa victory with another impressive result. Simon Zebo and Tommy Bowe claimed the tries for the hosts, with Johnny Sexton slotting 16 points from the tee. Australia outscored the home side three tries to two, with Nick Phipps claiming a brace and Bernard Foley also crossing. The resolve of Schmidt’s men mirrored the tenacity of the boss himself however, as Ireland fended off wave after wave of late attacks while the Kiwi head coach played down his illness. Centre Robbie Henshaw admitted he “didn’t notice” Schmidt was unwell in the build-up to Saturday’s autumn-closing Test. “Joe is an amazing coach and his attention to detail, as mentioned before, is unbelievable,” said Henshaw. “He gets you in the frame of mind where you have to know everything inside out. “It’s paying off, his work. He spots weaknesses in teams or where there is space in between teams. “He expects us to rise to the occasion. “We knew during the week it was going to be a physical game and that they were going to be ramped up. “We knew ourselves that we had to get one back on them from last year and we did that, thankfully. “He didn’t make so much of being unwell at all. I didn’t notice, he seemed pretty normal to me.” Hooker Best admitted Ireland may well have failed to close out Saturday’s 26-23 victory over Australia in previous campaigns. The Ulster front-rower conceded Ireland suffered “mental switch-offs” in a 32-15 defeat to Australia and the last-gasp 24-22 All Blacks loss in November 2013. The unwell head coach Schmidt delayed medical treatment to guide Ireland to their first autumn Test series clean sweep for eight years on Saturday, before being rushed to hospital to have his appendix removed. “The pleasing thing is that compared to where we were 12 months ago is that mentally, we stayed in,” said Best. “If you look at it 12 months ago we went mistake after mistake, mental switch-offs if you like, but this time round in a similar position, we didn’t. “But this year we stuck to our system, we came off the line, we hit and stuck, and we really put pressure on Australia. “Ultimately they were the ones under pressure at the end of the match because they were the ones who had to get points in some shape or form. “We put pressure on them, everyone stuck to their job and the big thing for us is that no one threw in the towel mentally. “There are a lot of great coaches out there, but Joe is certainly one of the best I’ve worked with. “He just expects a high level from you: and if you don’t toe the line and you don’t come up to his fairly tight standards then he finds someone else that will. Joe Schmidt’s “ruthless” selection policy has forced Ireland to shed mental weaknesses that were costing victories, according to Rory Best. Press Associationlast_img read more

Leinster’s Kevin McLaughlin retires due to concussion

first_img Governing body World Rugby have admitted looking into potential law changes around tackling in a bid to improve the sport’s safety. “It is upsetting and frustrating to have to retire when I feel I have so much left to give but it is the right decision and I am glad that our medical staff were so proactive in encouraging me to see a neurologist,” McLaughlin told Leinster’s website. “The support I have received from the club and my team-mates has been incredible and will help to soften the blow of having to having to retire from the game I love. “From a rugby perspective I have no regrets. “I was lucky enough to be involved in Leinster throughout a very successful and rewarding period during which I have learned a lot about life and made lifelong friends.” McLaughlin won eight caps for Ireland but also featured in Leinster’s 2011 and 2012 Heineken Cup final victories. The combative flanker had stepped up to captain Leinster at the start of the season in the absence of number eight Jamie Heaslip, away at the World Cup with Ireland. Leinster lost their opening Pro12 match 16-9 at Edinburgh on September 4, and after suffering a head injury McLaughlin has now been forced to retire. The 31-year-old suffered a concussion in Leinster’s season-opening Pro12 clash with Edinburgh and has since been advised to retire. McLaughlin’s premature retirement follows hot on the heels of former Wales flanker Jonathan Thomas quitting the sport after contracting epilepsy due to repetitive head trauma. Press Association ” Having sustained a concussion in the opening Pro12 game against Edinburgh Kevin was referred by the Leinster Rugby medical team to a leading neurologist, due to concerns about his increasing susceptibility to concussion and the length of recovery,” read Leinster’s statement. “Following tests it was recommended that it would be in his best long-term interests to stop playing.” Head coach Leo Cullen admitted he hopes McLaughlin will continue to help Leinster within their back-room set-up. “Kevin is a very popular member of the squad both on and off the pitch and thankfully he’s open to the possibility of helping out with us behind the scenes certainly in the short term and again I think that’s an indication of the esteem with which he is held within the group,” said Cullen. “Kevin is one of the most selfless players in our squad. He is the consummate pro and always put the team first.” Former Ireland flanker Kevin McLaughlin is the latest rugby star forced to retire due to concussion.last_img read more

Hillsman allows Coffey to make mistakes, continue to grow to become consistent scorer for Syracuse

first_img Facebook Twitter Google+ Head coach Quentin Hillsman sensed frustration mounting in point guard Rachel Coffey midway through last season.Bombarded with constant instructions from the coaching staff, Coffey veered away from playing her game and looked lost on the court. Turnovers and missed shots piled up as Coffey was out of her element.Then Hillsman had an idea.He decided to completely back off Coffey and let her play her game.The fix worked to perfection, as the point guard emerged as Syracuse’s star player over the final five games and carried the Orange to a berth in the semifinals of the Women’s National Invitation Tournament.AdvertisementThis is placeholder text“He used to take me out every time I made a mistake,” Coffey said. “Then he just let me play. I looked at it as this was my chance to play so I need to take advantage of it.”That’s exactly what she did. In the WNIT quarterfinal against Toledo, Coffey exploded for 23 points, including six three pointers, and six assists.Down by three with less than 10 seconds to go, Coffey knew she had to make a play. She burst left, crossed over to her right hand and pulled up for a fadeaway 30-footer.The year before, Coffey attempted a remarkably similar shot. Down by three against the same team in the same round of the WNIT, she unleashed a three in the waning seconds. That time, the shot clanked off the rim, as the Orange came up just short.When given a second chance, though, with redemption on her mind, Coffey drained the three-pointer, tying the game at 64. The Orange went on to win in thrilling fashion, 74-73, before falling to James Madison in the semifinals.The opportunity to play her game without constantly worrying about making a mistake paved the way for a dominant WNIT performance for Coffey, who averaged 11.8 points per game in SU’s WNIT run compared to 4.7 during the regular season.“Once I let her play her game and backed off so much instruction, she started playing better,” Hillsman said. “That was an easy fix. Step off, let her play and leave her alone.”After only scoring in double digits once through mid-January, Coffey finished in double figures seven times down the stretch and became Syracuse’s most reliable scoring option.“It was really humbling to know that I’m finally doing something here and contributing,” Coffey said. “It just really felt good that I was able to make that shot after what happened last season.”After her breakout performance late last season, Coffey has now solidified her spot as SU’s starting point guard going into her junior year. Hillsman said it is Coffey’s job unless someone takes it from her.Senior guard Carmen Tyson-Thomas said Coffey stepped into a leadership role during the WNIT last season and carried Syracuse toward the end of the season.“We had to find leadership from somewhere and you can’t just get it through your seniors,” Tyson-Thomas said. “You have to have a floor general. Seeing her come into that role has been amazing. It’s something that happened right before all of our eyes, and she stepped up and she’s been big for us.”On a roster full of seniors, Tyson-Thomas said Coffey is now the unquestioned leader on the court. Tyson-Thomas said the fact that Hillsman was a point guard himself makes Coffey’s job especially demanding because he expects a lot out of his star point guard.Despite these high expectations, Hillsman plans to continue to use a hands-off approach when coaching Coffey. Her instant offense and command of the floor were present in stretches last season, but this year Hillsman hopes to see that productivity every game from his starting point guard.“She really has matured into that role,” Hillsman said. “I think that as we’re going forward, her maturity and role are going to be the difference in a few games.“I’m just really happy that she got going at the end of the year, and hopefully that helps her confidence going into this season.” Comments Published on October 17, 2012 at 12:15 am Contact Trevor: tbhass@syr.edu | @TrevorHasslast_img read more

Murray eases into next round of US Open

first_imgMurray will now face Adrian Mannarino of France next.He’s joined by two other British players in the second round, as Johanna Konta beat Louisa Chirico, and Aljaz Bedene progressed after Ernests Gulbis retired injured in the third set.Continuing her comeback from long-term injury, Laura Robson was beaten by Russian Elena Vesnina, and James Ward lost to Thomaz Bellucci. The British number one got past the controversial Australian in four sets, 7-5, 6-3, 4-6, 6-1.Kyrgios is known for being outspoken – and entertaining – on court.Murray says it’s sometimes difficult to keep his focus when he plays him.last_img

Sports briefs: Calabar High School, Elaine Thompson, Bolt and Netball

first_imgCalabar High School star Christopher Taylor Calabar High School athlete shines at Jamaica InvitationalFans at the Jamaica Invitational in Kingston got a treat last weekend as Calabar High School star, Christopher Taylor, beat American great Lashawn Merritt to win the International Men’s 200-m in a time of 20.49 seconds. Merritt had to settle for second in 20.70.Despite a small audience at the invitational, those lucky enough to attend experienced history as the 18-year-old, who was running blind from lane seven with no one in lane eight, took the win.Anaso Jobodwana of South Africa was third in 20.70s. “It’s a motivation for me going forward seeing that I am just 18. I came up against the big boys and I came out victorious and this just motivates me for the World Juniors,” Taylor was quoted by the Jamaica Gleaner as saying.Merritt, who has a personal best of 19.74s, interrupted Taylor’s interview to congratulate the young Jamaican prodigy.“He is a great competitor. I have seen him run some 400s and I knew he was ready to come run in front of his home crowd and I congratulate him,” Merritt told the paper.Elaine Thompson For Prefontaine ClassicFresh off defeating a field of largely local athletes at the Jamaica International Invitational in Kingston last weekend, 2016 Olympic champion, Elaine Thompson, will take on a world-class field of sprinters in the 100-m this weekend at the Prefontaine Classic in Eugene, Oregon.Thompson will have to face the likes of 100-m World Champion, Torie Bowie; two-time World Champion Dafne Schippers, and World Indoor 60-m champion Murielle Ahoure from the Ivory Coast.The stacked field also includes Marie Josee Ta Lou, who defeated the Jamaican in the Diamond League season-opener in Doha to win in 10.85s to Thompson’s 10.93. Nigeria’s Blessing Okagbare, who was second in Doha in 10.90, is also in the line-up as is Great Britain’s Dina-Asher Smith and the USA’s Javainne Oliver.Bolt goes for bolts in JamaicaOlympic great, Usain Bolt, brought out a statue of himself – made mostly of real bolts as he celebrated the third Tracks & Records eatery in Jamaica recently. The Montego Bay eatery’s opening on the Hip Strip, included the grand unveiling of the famous “Bolt of Bolts” statue, created by German musician Vita Diedel Kloever.The grand opening welcomed Christopher Issa and the Crissa Entertainment Group to the Usain Bolt’s Tracks and Records family as the newest franchisee.Bolt has got 15 more Tracks & Records to open across the U.K. Now Netball Jamaica uncertain about Henry’s returnNetball Jamaica is set to hold a second meeting with disgruntled coach Sasher-Gaye Henry next week, in hopes she will return to the post she quit recently.At the first meeting last week, Netball Jamaica said it held productive discussions with Henry and had decided not to accept her resignation.But in a subsequent statement – her second since abruptly resigning two weeks ago – Henry stressed nothing had changed, though initial discussions with Netball Jamaica had been “cordial and constructive.”The local governing body spokesman, Wayne Lewis, said there was common belief Henry would return.Henry, along with fellow coach Marvette Anderson, guided Sunshine Girls to bronze at the Commonwealth Games in Gold Coast, Australia last month.Without warning, however, the former national player resigned her post a month later, citing “personal needs of my family” and her “increasing concerns about continuing professional weaknesses in the administration of the sport.”Lewis said Henry remained a vital part of the national setup, especially since there was a great relationship with the playerslast_img read more

Brazil need psychiatrist to get over Neymar injury

first_imgThe Brazil team have turned to a psychiatrist to help them get over the horror of golden boyNeymar’s injury, which has forced him to miss the rest of the World Cup. According to the Daily Mirror, Luis Felipe Scolari’s men are still in shock from the incident, and have needed to seek some professional help, in order clear the dark shadow that now looms over them, ahead of their clash with Germany tonight. Related articles– Brazil no longer play the beautiful game– Thiago Silva absence more important than Neymar – Jose Mourinho– Willian can star for Brazil in the absence of NeymarThiago SilvaBrazil’s star player suffered a bad challenge as Colombia defender Juan Zuniga went through his back, which turned out to be much worse than first feared as results later revealed that had indeed fractured his vertebra.  Brazil captain Silva – who will miss tonight’s semi-final due to a ban – made his feelings of disgust perfectly clear, by calling Zuniga a ‘coward’ and the defender also explained how formerChelsea psychiatrist Regina Brandao has prepared them to face the germans without their key man. “We just talk about a lot of things – Neymar being one of them – but she emphasised we all have to feel at ease,” Silva told reporters. “Neymar has already done what he had to do. Now it’s up to the other 22 to go out there and do everything for victory. He wanted to be here.”And now, a coward’s tackle – some people say it was normal, but I don’t think it was… That kind of challenge isn’t done. You can’t get the ball from someone by putting your knee into a player’s back, it’s not normal. But there you are.”Semi-Final The first of the two big semi-final showdowns will commence in Belo Horizonte tonight, between the two nations who have won the World Cup the most, as host Brazil take on Germany. As the team selection, beckons ever closer, Brazil boss Scolari faces some tough decisions.Scolari must choose whether he will make a more defensive mindset and play Luis Gustavo Paulinho and Fernandinho, or bring in Chelsea winger Willian, as he looks to compensate for the hole left by Neymar. Although, whichever tactical approach Scolari takes, he has confident that his side will do what’s expected of them and reach the final. He said: “If I play with three defensive midfielders, that’s one option. I will give the full-backs more freedom, obviously.“We’ve been working a lot to overcome obstacles since the beginning. We had to overcome problems and weaknesses to get to where we wanted, to get through the group and the round of 16 and so forth. We continue to do that. “We’ll play for us, for Neymar, but above all we’ll go after the goal the group has had since the beginning: to qualify for the final.”History Brazil are looking for their sixth World cup crown and will look to stop at nothing to try and accomplish that. There have been questions about this current crop of Brazilian stars, all of which have been answered so far but the big test comes tonight.They play a resilient and talented team, in the germans, who are capable of beating any side on their day and will no doubt have to play at the top of their game if they are to have a chance. Another key factor will be their support. The passionate crowd will have to drive their nation on like never before, with their two best players missing, if they are to make history and be the first Brazilian side to win the World Cup on home soil.last_img read more